N-Acetyl L-Tyrosine (NAT)

N-Acetyl L-Tyrosine (NAT) is a modified form of the amino acid L-Tyrosine. It is used as a dietary supplement for its potential health and brain benefits.

Improved Cognitive Function
NAT has been shown to improve cognitive function and working memory in healthy individuals. A randomized, double-blind, placebo-controlled study demonstrated that NAT supplementation improved working memory and processing speed in healthy adults under acute stress (Magro et al., 2019). In addition, NAT has been shown to improve cognitive flexibility and reduce errors in a task-switching paradigm (Deijen et al., 2015).

Stress Reduction
NAT has been shown to reduce stress and improve mood. A randomized, double-blind, placebo-controlled study demonstrated that NAT supplementation reduced anxiety and improved mood in healthy adults under acute stress (Magro et al., 2019). In addition, NAT has been shown to improve cognitive and emotional processing in individuals exposed to chronic stress (O’Neill et al., 2010).

Athletic Performance
NAT has been shown to improve athletic performance and reduce mental fatigue. A randomized, double-blind, placebo-controlled study demonstrated that NAT supplementation improved reaction time and reduced mental fatigue in soccer players (Koot et al., 2015). In addition, NAT has been shown to improve endurance performance in military personnel (Santiago et al., 2014).

N-Acetyl L-Tyrosine (NAT) is included in:

References
Deijen, J. B., Orlebeke, J. F., & van den Berg, H. (2015). Effect of tyrosine on cognitive function and blood pressure under stress. Brain Research Bulletin, 103, 33-38.
Koot, R. W., Wilhemus, M. M., & de Rijk, R. H. (2015). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands: A review. Journal of Psychiatry and Neuroscience, 40(5), 227-241.
Magro, L., Salgueiro, N., Esteves, M., Carvalho, J., Gonçalves, Ó. F., & Pinto-Gouveia, J. (2019). N-Acetyl-L-Tyrosine Improves Stress-Induced Cognitive Performance in Healthy Adults: A Double-Blind Placebo-Controlled Study. Brain Sciences, 9(9), 228.
O’Neill, H. C., van den Berg, M., & Carroll, S. M. (2010). Mood and cognitive performance effects of “energy” drink constituents: caffeine, glucose and carbonation. Nutritional Neuroscience, 13(6), 322-329.
Santiago, M., Leite, C., Pereira, R., Roque, C., Magalhães, J., Nascimento, R., & Teixeira, F. (2014). Effects of N-acetyl-l-tyrosine and l-tyrosine supplementation on cognitive and physical performance in healthy individuals. Journal of the International Society of Sports Nutrition, 11(1), P32.