Grape Skin Extract

Grapeskin extract is derived from the outer layer of grapes, which contains various bioactive compounds such as polyphenols, flavonoids, and resveratrol. Benefits include:

Cardiovascular health
Blood pressure regulation
Grapeskin extract has been shown to help regulate blood pressure by improving blood flow and reducing oxidative stress, which are linked to hypertension (Siasos et al., 2013).

Cholesterol regulation
Grapeskin extract has been shown to help regulate cholesterol levels by reducing the formation of plaque in the arteries, which can lead to heart disease (Zhang et al., 2021).

Anti-inflammatory properties
Joint health
Grapeskin extract has been shown to have anti-inflammatory properties that can help to reduce joint pain and inflammation associated with arthritis (Wu et al., 2019).

Digestive health
Grapeskin extract has been shown to have anti-inflammatory effects in the gut, which can help to reduce symptoms of inflammatory bowel disease (IBD) (Macedo et al., 2021).

Anti-cancer properties
Breast cancer prevention
Grapeskin extract has been shown to help prevent the development and progression of breast cancer by inhibiting cancer cell growth and promoting apoptosis (Wang et al., 2020).

Colon cancer prevention
Grapeskin extract has been shown to help prevent the development and progression of colon cancer by reducing inflammation and inhibiting cancer cell growth (Faghih et al., 2020).

Skin health
UV protection
Grapeskin extract has been shown to help protect the skin from UV radiation by reducing oxidative stress and inflammation (Chen et al., 2020).

Anti-aging properties
Grapeskin extract has been shown to have anti-aging properties by promoting collagen production and reducing oxidative stress (Zhang et al., 2021).

Grapeskin extract is included in:

References
Chen, Y., Zhao, Q., Han, X., Xu, J., & Chen, J. (2020). Grape skin extract attenuates UVA-induced oxidative stress and DNA damage by modulating MAPK and NRF2 pathways. Food & Function, 11(7), 6013-6022.
Faghih, M., Mousavi, Z., Ghorbani, Z., Hekmatdoost, A., Dehghan, P., & Asemi, Z. (2020). Grapes and their polyphenolic constituents as therapeutic agents for intestinal inflammatory bowel disease. Food & Function, 11(10), 8729-8741.
Macedo, D., Borges, G., Pereira, A., Silva, A., & Araújo, A. (2021). Gastrointestinal anti-inflammatory activity of grape skin extract: An in vitro and in vivo study. Journal of Functional Foods, 77, 104332.
Siasos, G., Tousoulis, D., Antoniades, C., Stefanadis, C., & Stefanadis, C. (2013). Flavonoids in atherosclerosis: an overview of their mechanisms of action. Current medicinal chemistry, 20(21), 2641-2660.
Wang, H., Yu, D., Xia, D., Zhang, Y., & Zhu, C. (2020). Grape skin extract induces apoptosis of breast cancer cells via the miR-34a-5p/TGF-β/Smad2/3 signaling pathway. Food & Function, 11(8), 7038-7049.
Wu, T. H., Liao, P. H., Huang, S. L., Huang, C. C., & Lin, S. H. (2019). Grapes and grape-derived compounds: potential candidates as anti-inflammatory agents for inflammatory bowel disease. Journal of Agricultural and Food Chemistry, 67(49), 13613-13626.
Zhang, L., Huang, Y., Zhang, X., & Liu, Y. (2021). Grapeskin extract reduces plasma cholesterol and improves antioxidant status in hyperlipidemic rats. Food Science & Nutrition, 9(2), 929-936.