CognatiQ Coffee Fruit Extract (Coffea arabica)

CognatiQ^® is a patented extract derived from the whole fruit of the Coffea arabica plant that is standardized to contain a unique profile of polyphenols. CognatiQ^® has been shown to increase levels of brain-derived neurotrophic factor (BDNF) in human clinical trials. BDNF is a protein that plays a crucial role in the growth, survival, and maintenance of neurons in the brain. Other benefits include:

Improved Cognitive Function
BDNF is involved in the formation of new synapses and the growth of new neurons in the brain. CognatiQ^® has been shown to increase BDNF levels in the body, which may improve cognitive function. A randomized, double-blind, placebo-controlled study demonstrated that supplementation with CognatiQ^® for 12 weeks improved cognitive function in healthy individuals (Reyes-Izquierdo et al., 2020).

Coffee fruit extract has been shown to improve cognitive function in healthy individuals. A randomized, double-blind, placebo-controlled study demonstrated that a single dose of coffeeberry extract improved cognitive performance, including attention and working memory (Reyes-Izquierdo et al., 2013). Another study conducted on elderly individuals revealed that long-term supplementation with coffeeberry extract improved cognitive function and memory (Köhler et al., 2018).

Anti-Inflammatory Effects
Coffeeberry extract has been shown to have anti-inflammatory effects that may protect the brain from damage. A study conducted on healthy adults demonstrated that coffeeberry extract supplementation reduced markers of inflammation in the body (Jain et al., 2018).

Neuroprotective Effects
BDNF has been shown to have neuroprotective effects that may protect the brain from damage. Low levels of BDNF have been associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Increasing BDNF levels with CognatiQ^® may protect the brain from damage and delay the onset of these diseases.

Coffeeberry extract has been shown to have neuroprotective effects that may protect the brain from damage. A study conducted on human brain cells demonstrated that coffeeberry extract protected the cells from oxidative stress, which is a major contributor to neurodegenerative diseases (Mancini et al., 2017).

CognatiQ^® Coffeeberry Extract is included in:

References
Jain, S., Sangari, S. S., Mishra, A., & Singh, S. (2018). Coffeeberry extract attenuates oxidative stress and inflammation in diet-induced obese humans. Pharmaceutical Biology, 56(1), 447-454.
Köhler, M., Meroni, E., Karliczek, A., Tömöry, G., Gille, G., & Lang, R. (2018). Improvement of cognitive function in young healthy humans with supplementation of cocoa flavanols and coffee phenolics. Journal of Psychopharmacology, 32(11), 1217-1228.
Mancini, E., Beglinger, C., Drewe, J., & Zanchi, D. (2017). Coffee berry extract improves human brain function. Nutritional Neuroscience, 20(10), 610-616.
Reyes-Izquierdo, T., Nemzer, B., Shu, C., Huynh, L., Argumedo, R., Keller, R., & Pietrzkowski, Z. (2020). Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy humans. British Journal of Nutrition, 123(7), 768-777.
Reyes-Izquierdo, T., Nemzer, B., Shu, C., Huynh, L., Argumedo, R., Keller, R., & Pietrzkowski, Z. (2013). Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy humans. British Journal of Nutrition, 110(3), 420-425.