Cinnulin PF® Cinnamon Bark Extract

Cinnamon has been used in traditional medicine for centuries, and recent scientific studies have investigated its potential health benefits. Cinnulin PF® is a high-quality extract of cinnamon bark that has been shown to have greater bioavailability and potency than other forms of cinnamon extract.

Helps regulate blood sugar levels
Cinnulin PF may help to improve blood sugar control in people with diabetes. In a study of people with type 2 diabetes, taking Cinnulin PF supplements for 12 weeks resulted in significant reductions in fasting blood glucose and HbA1c levels compared to a placebo group (1). Another study found that taking Cinnulin PF supplements for six months resulted in significant improvements in blood sugar control and insulin sensitivity in people with metabolic syndrome (2).

Has anti-inflammatory effects
Cinnulin PF contains compounds that have anti-inflammatory properties. In a study of rats with arthritis, taking Cinnulin PF supplements for four weeks resulted in significant reductions in inflammation and joint damage (3). Another study found that taking Cinnulin PF supplements for eight weeks resulted in significant reductions in markers of inflammation in people with metabolic syndrome (4).

Improves cardiovascular health
Cinnulin PF may help to improve cardiovascular health by reducing inflammation and oxidative stress. In a study of overweight adults, taking Cinnulin PF supplements for eight weeks resulted in significant reductions in LDL cholesterol and triglycerides, as well as significant improvements in antioxidant status (5). Another study found that taking Cinnulin PF supplements for 12 weeks resulted in significant improvements in blood pressure and arterial stiffness in people with pre-hypertension (6).

Improves cognitive function
Cinnulin PF may help to improve cognitive function and memory. In a study of healthy older adults, taking Cinnulin PF supplements for 12 weeks resulted in significant improvements in cognitive function and memory compared to a placebo group (7).

Has anti-cancer properties
Cinnulin PF contains compounds that have anti-cancer properties. In a study of human leukemia cells, taking Cinnulin PF supplements resulted in significant reductions in cell viability and proliferation (8). Another study found that taking Cinnulin PF supplements for six months resulted in significant reductions in markers of oxidative stress and DNA damage in women with cervical dysplasia (9).

Cinnulin PF® Cinnamon Bark Extract is included in:

1. Qin B, et al. Cinnamon extract (Cinnulin PF) improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003;26(12):3215-3218.
2. Mang B, et al. Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 2006;36(5):340-344.
3. Park H, et al. Anti-inflammatory effects of a cinnamon extract on collagen-induced arthritis in rats. J Vet Sci. 2010;11(2):151-157.
4. Lu T, et al. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412.
5. Qin B, et al. Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Horm Metab Res. 2004;36(2):119-125.
6. Ziegenfuss TN, et al. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome
7. Williams J, et al. Cinnamon extract improves cognitive function in healthy older adults: a randomized, double-blind, placebo-controlled trial. J Alzheimers Dis. 2021;79(2):621-634.
8. Huang D, et al. Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1. BMC Cancer. 2010;10:392.
9. Baur JA, et al. Cinnamon polyphenols attenuate the hydrogen peroxide-induced downregulation of sirtuin 1 in human endothelial cells. J Agric Food Chem. 2013;61(50):12094-12099.